Ginny L. Bumgardner MD PhD FACS
Ohio State University Medical Center
Dr. Bumgardner is a Professor of Surgery and abdominal transplant surgeon at The Ohio State University Medical Center in Columbus, Ohio. She pursued her undergraduate training at the College of William and Mary where she graduated summa cum laude in 1979. She was elected to membership in Alpha Omega Alpha in 1982 and received her medical degree in 1983 from the University of Virginia. Dr. Bumgardner completed her internship and general surgery residency training at the University of Minnesota in 1991 and earned a Ph.D. while at the University of Minnesota where she performed dissertation research in transplant immunobiology. She completed her surgery transplant fellowship training at the University of California San Francisco in 1993. She is a Fellow of the American College of Surgeons. Dr. Bumgardner joined the Ohio State University Medical Center (OSUMC) Department of Surgery as an Assistant Professor in the Division of Transplantation in 1993.
While at OSUMC Dr. Bumgardner has balanced a clinical career in transplant surgery with laboratory research in transplant immunobiology. More recently, she has assumed educational administrative roles in the Department of Surgery and at the College of Medicine. She has mentored many fellows in transplant surgery and many research trainees over the years from undergraduate to postdoctoral level students. The success of her trainees is a benchmark for productive mentorship. Based on her experience in research education and training, in 2007 the Dean recruited Dr. Bumgardner to serve as Associate Dean for Research Education in the College of Medicine. In this role she oversees the medical student research program and the COM Masters of Science in Medical Science Program for residents and fellows in training at OSUMC. Along with Joanna Groden PhD, she co-directs OSU HHMI Med into Grad Scholars Program which seeks to expose promising predoctoral graduate students early on in their careers to the medical field in hopes that this will inform their current basic research, prepare them for future translation of basic science discoveries to clinical application and prepare them to collaborate with physicians in the future. Dr. Bumgardner also serves as the Co-Director of the OSU Center for Clinical & Translational Science (CCTS) Research Education Resources & Special Programs. Dr. Bumgardner has been voted one of the Top Doctors in the USA and selected for Who’s Who in Medicine.
Dr. Bumgardner’s lab-based research focuses on basic mechanisms of alloimmune mediated hepatocyte injury. She introduced the functional hepatocyte transplantation model using transgenic hepatocytes to study the in vivo immunobiology of allogeneic hepatocellular transplantation in 1998. Her studies using this model in comparison to genetically matched islet transplant and heart transplant have demonstrated the importance of tissue (parenchymal cell type) in determining the phenotype and effector mechanisms comprising alloimmune responses after transplantation. Work from her lab has demonstrated that allogeneic liver parenchymal cells stimulate the maturation of CD4-independent and CD4-dependent allospecific CD8+ cytolytic effectors (allo-CTLs). These CTL subsets are distinct in magnitude of in vivo cytotoxic effector function, CD8+ T cell recall responses in vivo, molecular effector mechanisms which mediate cytotoxicity. Furthermore, these two pathways are differentially susceptible to conventional and experimental immunosuppressive agents. Her lab is the first to show that alloantibodies also mediate immune damage of transplanted hepatocytes by a macrophage-dependent mechanism. Studies are ongoing to investigate novel mechanisms governing the regulation of posttransplant alloantibody production in an animal model and to investigate translational aspects of these studies in humans. Dr. Bumgardner has authored more than 120 articles and book chapters. She serves as a reviewer for many journals and previously served on the Editorial Board of the American Journal of Transplantation (AJT). Dr. Bumgardner has been an ad hoc member of several NIH study sections and currently serves as a standing member of an NIAID study section.
Dr. Bumgardner collaborates with a number of her transplant colleagues in clinical research studies. Her clinical research interests include infectious complications of immunosuppression, posttransplant recurrence of autoimmune diseases and issues related to pregnancy after transplantation. More recently, she has become interested in transplant workforce issues.
Nationally, Dr. Bumgardner has held a number of leadership roles in transplant professional organizations. Dr. Bumgardner currently serves as Chair of the American Society of Transplant Surgery (ASTS) Awards Committee and has chaired the Adhoc ASTS Workforce Committee. She serves as an elected member of the American Association for the Study of Liver Diseases (AASLD) Board of Directors and has previously served as an elected member of the Board of Directors for the American Society of Transplantation (AST). She has previously served as Chair of the AST Kidney Pancreas Committee and a member of the AST Public Policy Committee. In 2005, she provided testimony on behalf of the Transplant Roundtable (a coalition of 12 transplant organizations) to the U.S. House of Representatives Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies to request $25 million in funding for the Organ Donation and Recovery Improvement Act of 2004.